Valproic acid ( VPA;2-Propylpentanoic Acid )

Catalog No. M16914 CAS No. 99-66-1

A HDAC inhibitor that selectively inhibits the catalytic activity of class I HDACs, and induces proteasomal degradation of HDAC2.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

Valproic acid
Note

Research use only, not for human use.
Brief Description

A HDAC inhibitor that selectively inhibits the catalytic activity of class I HDACs, and induces proteasomal degradation of HDAC2.
Description

A HDAC inhibitor that selectively inhibits the catalytic activity of class I HDACs, and induces proteasomal degradation of HDAC2; induces differentiation of carcinoma cells, transformed hematopoietic progenitor cells and leukemic blasts from AML patients; reduces tumor growth and metastasis formation in animal model.Migraine Approved
Synonyms

VPA;2-Propylpentanoic Acid
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

GABA; Sodium Channel; HDACs
Research Area

Neurological Disease
Indication

Migraine

Chemical Information

CAS Number

99-66-1
Formula Weight

144.21
Molecular Formula

C8H16O2
Purity

>98% (HPLC)
Solubility

10 mM in H2O
SMILES

CCCC(CCC)C(O)=O
Chemical Name

Pentanoic acid, 2-propyl-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Krmer OH, et al. EMBO J. 2003 Jul 1;22(13):3411-20.
2. Gttlicher M, et al. EMBO J. 2001 Dec 17;20(24):6969-78.
3. Phiel CJ, et al. J Biol Chem. 2001 Sep 28;276(39):36734-41.

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